发明授权
- 专利标题： Method for preparing submicron particle suspensions
- 专利标题（中）： 亚微米颗粒悬浮液的制备方法
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申请号： US10021692申请日： 2001-12-12
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公开(公告)号： US06884436B2公开(公告)日： 2005-04-26
- 发明人: James E. Kipp , Joseph Chung Tak Wong , Mark J. Doty , Jane Werling , Christine L. Rebbeck , Sean Brynjelsen
- 申请人： James E. Kipp , Joseph Chung Tak Wong , Mark J. Doty , Jane Werling , Christine L. Rebbeck , Sean Brynjelsen
- 申请人地址： US IL Deerfield
- 专利权人： Baxter International Inc.
- 当前专利权人： Baxter International Inc.
- 当前专利权人地址： US IL Deerfield
- 代理商 Michael C. Mayo; Joseph A. Fuchs
- 主分类号： A61K9/10
- IPC分类号： A61K9/10 ; A61K9/14 ; A61K9/16 ; A61K31/495 ; A61K31/496 ; B01J13/00
摘要：
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
公开/授权文献
- US20030206959A9 Method for preparing submicron particle suspensions 公开/授权日：2003-11-06