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发明授权
US06887852B1 Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer 有权
重组因子VIII的药物制剂冻干，无白蛋白作为稳定剂

Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer
摘要：
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
摘要（中）：

公开了用作血友病A的治疗制剂的重组因子VIII的冻干制剂。重组因子VIII的冻干制剂通过使用包含6至100mM L-精氨酸，3.5至50mM L- 异亮氨酸和10至100mM的L-谷氨酸作为稳定重组因子VIII的稳定剂，其在冻干期间表现出不稳定的活性，而不是使用人血清白蛋白。

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