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发明授权
US06887869B2 Mikanolide derivatives, their preparation and therapeutic uses 失效
米考洛德衍生物，其制备和治疗用途

Mikanolide derivatives, their preparation and therapeutic uses
摘要：
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom
摘要（中）：

本发明涉及新颖的米卡尼定衍生物，其制备方法及其治疗用途，特别是抗癌和抗病毒剂。 化合物对应于对应于通式（I）的通式（1）1和2其中：R 1 表示H，SR 4或NR 4 R 5; R 2表示SR 6或NR 6 R 7; R 3表示OH，O（CO）R 14，OSiR 15 R 16 R 17， O（CO）OR 18或O（CO）NHR 18，基团R 4，R 3， R 6，R 15，R 16和R 17独立地表示（特别是）烷基，基团R 时，R 1不表示氢原子

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