- 专利标题： Compositions useful for the treatment of pathologies responding to the activation of PPAR-γ receptor
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申请号： US10471786申请日： 2002-03-01
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公开(公告)号： US06897235B2公开(公告)日： 2005-05-24
- 发明人: Claudio Pisano , Teresa Riccioni
- 申请人： Claudio Pisano , Teresa Riccioni
- 申请人地址： IT Rome
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： IT Rome
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： ITRM2001A0136 20010315
- 国际申请： PCTIT02/00127 WO 20020301
- 国际公布： WO0207429 WO 20020926
- 主分类号： C07D493/10
- IPC分类号： C07D493/10 ; A61K31/203 ; A61K31/365 ; A61K45/00 ; A61K45/06 ; A61P3/10 ; A61P5/50 ; A61P7/00 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; A61K31/35
摘要：
This invention features the use of the spirolaxine of formula (I) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the Type 2 insulin-resistant diabetes. This invention also features a pharmaceutical composition in which the spirolaxine of formula (I) acts as active principle in association with the all-trans retinoic acid of formula (II) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the acute malignant haemopathies.
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