发明授权
US06908930B2 4-substituted 7-AZA-indolin-2-ones and their use as protein kinase inhibitors
失效
4-取代的7-AZA-二氢吲哚-2-酮及其作为蛋白激酶抑制剂的用途
- 专利标题： 4-substituted 7-AZA-indolin-2-ones and their use as protein kinase inhibitors
- 专利标题（中）： 4-取代的7-AZA-二氢吲哚-2-酮及其作为蛋白激酶抑制剂的用途
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申请号： US10622787申请日： 2003-07-21
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公开(公告)号： US06908930B2公开(公告)日： 2005-06-21
- 发明人: Congxin Liang , Li Sun , Chung Chen Wei , Peng Cho Tang , Gerald McMahon , Klaus Peter Hirth , Jingrong Cui
- 申请人： Congxin Liang , Li Sun , Chung Chen Wei , Peng Cho Tang , Gerald McMahon , Klaus Peter Hirth , Jingrong Cui
- 申请人地址： US CA San Diego
- 专利权人： Sugen, Inc.
- 当前专利权人： Sugen, Inc.
- 当前专利权人地址： US CA San Diego
- 代理商 Peter C. Richardson; Bryan C. Zielinski; Vincent P. Liptak
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/519 ; A61K31/5377 ; A61P1/00 ; A61P1/18 ; A61P3/00 ; A61P5/00 ; A61P9/00 ; A61P11/00 ; A61P11/06 ; A61P13/00 ; A61P15/00 ; A61P19/00 ; A61P25/00 ; A61P35/00 ; A61P37/08 ; A61P43/00 ; C07D471/04 ; C07D487/04
摘要：
This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention further relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.
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