发明授权
US06908940B2 Imidazole compounds and their use as adenosine deaminase inhibitors
失效
咪唑化合物及其作为腺苷脱氨酶抑制剂的用途
- 专利标题： Imidazole compounds and their use as adenosine deaminase inhibitors
- 专利标题（中）： 咪唑化合物及其作为腺苷脱氨酶抑制剂的用途
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申请号： US10169757申请日： 2001-01-19
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公开(公告)号： US06908940B2公开(公告)日： 2005-06-21
- 发明人: Kiyoshi Tsuji , Tadashi Terasaka , Katsuya Nakamura
- 申请人： Kiyoshi Tsuji , Tadashi Terasaka , Katsuya Nakamura
- 申请人地址： JP Osaka
- 专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权： AUPQ5157 20000119
- 国际申请： PCT/JP01/00342 WO 20010119
- 国际公布： WO01/53271 WO 20010726
- 主分类号： A61K31/4164
- IPC分类号： A61K31/4164 ; A61K31/4178 ; A61K31/4245 ; A61K31/427 ; A61K31/4439 ; A61P9/10 ; A61P29/00 ; A61P35/02 ; A61P37/02 ; A61P37/06 ; A61P43/00 ; C07D233/64 ; C07D233/90 ; C07D401/12 ; C07D403/12 ; C07D403/14 ; C07D409/12 ; C07D409/14 ; C07D413/12 ; C07D417/12 ; C07D417/14 ; C07D233/54
摘要：
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryloxy, or aryl which is optionally substituted with suitable substituent(s); R2 is lower alkyl; R3 is hydroxy or protected hydroxy; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
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