发明授权
- 专利标题： Humanized immunoglobulin reactive with B7 therewith
- 专利标题（中）： 与B7反应的人源化免疫球蛋白
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申请号： US09339596申请日： 1999-06-24
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公开(公告)号： US06913747B1公开(公告)日： 2005-07-05
- 发明人: Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
- 申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
- 专利权人： Genetics Institute, LLC
- 当前专利权人： Genetics Institute, LLC
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C12N15/13 ; C12N15/63
摘要：
The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
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