- 专利标题: Pyruvate derivatives
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申请号: US10138937申请日: 2002-05-03
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公开(公告)号: US06916850B2公开(公告)日: 2005-07-12
- 发明人: Bing Wang , Guy Miller , Wei Zhang
- 申请人: Bing Wang , Guy Miller , Wei Zhang
- 申请人地址: US CA Santa Clara
- 专利权人: Galileo Pharmaceuticals, Inc.
- 当前专利权人: Galileo Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Santa Clara
- 代理商 David A. Lowin; Gloria Pfister
- 主分类号: A61K31/12
- IPC分类号: A61K31/12 ; A61K31/16 ; A61K31/215 ; A61K31/223 ; A61K38/00 ; A61P9/10 ; C07C249/12 ; C07C251/60 ; C07C319/20 ; C07C323/57 ; C07C323/60 ; C07D207/16 ; C07D207/22 ; C07D207/24 ; C07D211/62 ; C07D211/74 ; C07D211/78 ; C07D213/30 ; C07D217/04 ; C07D233/42 ; C07D233/54 ; C07D233/84 ; C07D235/28 ; C07D239/78 ; C07D249/14 ; C07D271/10 ; C07D271/113 ; C07D277/16 ; C07D277/74 ; C07D279/12 ; C07D285/12 ; C07D285/125 ; C07D285/135 ; C07D295/13 ; C07D295/15 ; C07D295/185 ; C07D339/08 ; C07D345/00 ; C07D405/12 ; C07D473/38 ; C07K5/02 ; C07K5/093 ; C07C317/04 ; A61K31/10 ; C07C321/14
摘要:
Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.
公开/授权文献
- US20030013847A1 Pyruvate derivatives 公开/授权日:2003-01-16