发明授权
- 专利标题: Respiratory syncytial virus replication inhibitors
- 专利标题(中): 呼吸道合胞病毒复制抑制剂
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申请号: US10030202申请日: 2000-06-20
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公开(公告)号: US06924287B1公开(公告)日: 2005-08-02
- 发明人: Frans Eduard Janssens , Kathleen Petrus Marie-José Meersman , François Maria Sommen , Jérôme Emile Georges Guillemont , Jean Fernand Armand Lacrampe , Koenraad Jozef Lodewijk Marcel Andries
- 申请人: Frans Eduard Janssens , Kathleen Petrus Marie-José Meersman , François Maria Sommen , Jérôme Emile Georges Guillemont , Jean Fernand Armand Lacrampe , Koenraad Jozef Lodewijk Marcel Andries
- 申请人地址: BE
- 专利权人: Janssen Pharmacatica, N.V.
- 当前专利权人: Janssen Pharmacatica, N.V.
- 当前专利权人地址: BE
- 代理机构: Woodcock Washburn LLP
- 优先权: EP99202087 19990628; EP00200452 20000211
- 国际申请: PCT/EP00/05676 WO 20000620
- 国际公布: WO01/00611 WO 20010104
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/4184 ; A61K31/4188 ; A61K31/443 ; A61K31/4439 ; A61K31/454 ; A61K31/4545 ; A61K31/4745 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/55 ; A61K31/551 ; A61P31/12 ; A61P31/14 ; C07D401/06 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D401/12
摘要:
This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N— wherein each hydrogen atom may optionally be replaced; Q is a radical of formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), G is a direct bond or C1-10alkanediyl; R1 is an optionally substituted monocyclic heterocycle; for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections. Certain compounds of formula (I) are new.