发明授权
- 专利标题： Human chemokine beta-10 mutant polypeptides
- 专利标题（中）： 人趋化因子β-10突变体多肽
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申请号： US10125451申请日： 2002-04-19
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公开(公告)号： US06936688B2公开(公告)日： 2005-08-30
- 发明人: Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
- 申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
- 申请人地址： US MD Rockville US PA King of Prussia
- 专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corp.
- 当前专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corp.
- 当前专利权人地址： US MD Rockville US PA King of Prussia
- 代理机构： Human Genome Sciences, Inc.
- 主分类号： A61K38/19
- IPC分类号： A61K38/19 ; C07H21/04 ; C07K14/52 ; C12N5/06 ; C12N5/10 ; C12N15/19 ; C12N15/63 ; C12P21/02
摘要：
Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
公开/授权文献
- US20030022314A1 Human chemokine beta-10 mutant polypeptides 公开/授权日：2003-01-30
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