A multi-piece golf ball includes a core having a diameter of 30 to 40 mm, at least one intermediate layer including the outermost layer having a thickness of 0.5 to 2.0 mm, and a cover having a thickness of 1.0 to 3.0 mm. The cover is made from a material obtained by dispersedly blending at least one kind of silicone powder selected from a silicone rubber powder, a silicon resin powder, and a composite powder thereof, in a main resin component containing an ionomer resin in an amount of 50% by weight or more. Dimples of the number of 300 to 550 pieces are formed in the surface of the golf ball in such a manner that a dimple total volume ratio VR is in a range of 0.85% or less. The multi-piece golf ball is excellent in resilience, flight distance characteristic, and feel of hitting.