发明授权
US06939964B2 Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
有权
（ - ） - 6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H-3,1-苯并恶嗪-2-酮的晶体形式
- 专利标题： Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
- 专利标题（中）： （ - ） - 6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H-3,1-苯并恶嗪-2-酮的晶体形式
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申请号： US10891749申请日： 2004-06-24
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公开(公告)号： US06939964B2公开(公告)日： 2005-09-06
- 发明人: Louis S. Crocker , Joseph L. Kukura, II , Andrew S. Thompson , Christine Stelmach , Steven D. Young
- 申请人： Louis S. Crocker , Joseph L. Kukura, II , Andrew S. Thompson , Christine Stelmach , Steven D. Young
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Kenneth R. Walton; Valerie J. Camara
- 主分类号： C07D265/18
- IPC分类号： C07D265/18
摘要：
The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.