发明授权
- 专利标题： Rhenium and technetium complexes containing a hypoxia-localizing moiety
- 专利标题（中）： 含有缺氧定位部分的铼和锝络合物
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申请号： US10742348申请日： 2003-12-19
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公开(公告)号： US06958141B2公开(公告)日： 2005-10-25
- 发明人: Karen Linder , Adrian D. Nunn , David P. Nowotnik , Kondareddiar Ramalingam , Richard J. DiRocco , William L. Rumsey , John P. Pirro
- 申请人： Karen Linder , Adrian D. Nunn , David P. Nowotnik , Kondareddiar Ramalingam , Richard J. DiRocco , William L. Rumsey , John P. Pirro
- 申请人地址： NL Amsterdam
- 专利权人： Bracco International B.V.
- 当前专利权人： Bracco International B.V.
- 当前专利权人地址： NL Amsterdam
- 代理机构： Kramer, Levin, Naftali & Frankel LLP
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; C07C251/38 ; A61K49/00
摘要：
Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.