A modular drill guide for use in securing a spinal fixation plate to a spine is provided. The drill guide generally includes a shaft having a proximal end and a distal end adapted to engage a spinal fixation plate, and at least one guide member removably and replaceably matable to the shaft. The guide member can have a connector member with at least one bore extending therethrough for receiving at least a portion of the shaft, and at least one barrel formed thereon and defining a lumen for receiving a tool, such as an awl, a drill bit, a fastener, or a driver device. The shaft can optionally be coupled to an elongate member having a proximal end and a distal end. The barrel(s) include a bore formed therethrough for receiving a tool.