发明授权
- 专利标题: Cell-specific gene delivery vehicles
- 专利标题(中): 细胞特异性基因递送载体
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申请号: US08541191申请日: 1995-10-11
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公开(公告)号: US06962686B2公开(公告)日: 2005-11-08
- 发明人: Jon F. Kayyem , Thomas J. Meade , Scott E. Fraser
- 申请人: Jon F. Kayyem , Thomas J. Meade , Scott E. Fraser
- 申请人地址: US CA Pasadena
- 专利权人: California Institute of Technology
- 当前专利权人: California Institute of Technology
- 当前专利权人地址: US CA Pasadena
- 代理机构: Dorsey & Whitney LLP
- 代理商 Richard F. Trecartin; Robin M. Silva
- 主分类号: A61K49/12
- IPC分类号: A61K49/12 ; A61K51/00 ; A61M36/14
摘要:
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
公开/授权文献
- US20050074403A1 CELL-SPECIFIC GENE DELIVERY VEHICLES 公开/授权日:2005-04-07