发明授权
- 专利标题: Oxindole derivatives
- 专利标题(中): 羟吲哚衍生物
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申请号: US10362739申请日: 2001-08-23
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公开(公告)号: US06964977B2公开(公告)日: 2005-11-15
- 发明人: Philip Anthony Harris , Robert N Hunter , Robert Walton McNutt, Jr. , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael Robert Peel , Edgar Raymond Wood, III
- 申请人: Philip Anthony Harris , Robert N Hunter , Robert Walton McNutt, Jr. , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael Robert Peel , Edgar Raymond Wood, III
- 申请人地址: US PA Philadelphia
- 专利权人: SmithKline Beecham Corporation
- 当前专利权人: SmithKline Beecham Corporation
- 当前专利权人地址: US PA Philadelphia
- 代理商 John L. Lemanowicz
- 国际申请: PCT/US01/26286 WO 20010823
- 国际公布: WO02/20513 WO 20020314
- 主分类号: A61K31/404
- IPC分类号: A61K31/404 ; A61K31/4045 ; A61K31/405 ; A61K31/4184 ; A61K31/4196 ; A61K31/4245 ; A61K31/454 ; A61K31/53 ; A61P7/02 ; A61P9/10 ; A61P29/00 ; A61P29/02 ; A61P35/00 ; A61P43/00 ; C07D209/14 ; C07D209/34 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D487/04 ; A61K31/415
摘要:
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
公开/授权文献
- US20030225090A1 Oxindole derivatives 公开/授权日:2003-12-04