发明授权
US06969704B1 Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
失效
抑制早期生长反应-1蛋白（Egr-1）以减少受试者血管损伤的方法
- 专利标题： Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
- 专利标题（中）： 抑制早期生长反应-1蛋白（Egr-1）以减少受试者血管损伤的方法
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申请号： US09648389申请日： 2000-08-25
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公开(公告)号： US06969704B1公开(公告)日： 2005-11-29
- 发明人: David Pinsky , David M. Stern , Shi-Fang Yan
- 申请人： David Pinsky , David M. Stern , Shi-Fang Yan
- 申请人地址： US NY New York
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White, Esq.
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/07 ; C07H21/04 ; C12Q1/68
摘要：
The invention provides a method for reducing damage to an ischemic tissue which comprises contacting cells of the tissue with an inhibitor of Early Growth Response Factor-1 Protein (Egr-1). In addition, the invention provides a method for reducing vascular injury during reperfusion of an ischemic tissue in a subject which comprises contacting the tissue with a compound which inhibits expression of Early Growth Response Factor-1 (Egr-1) protein in the tissue so as to reduce vascular injury in the tissue during reperfusion. wherein the inhibitor is a nucleic acid consisting essentially of the polynucleotide sequence 5′-CTTGGCCGCTGCCAT-3′ (SEQ ID NO:1). In one embodiment of the invention, the subject has suffered a stroke, or a myocardial infarction. In another embodiment of the invention, the subject is undergoing or has undergone angioplasty, cardiac surgery, vascular surgery, or organ transplantation.
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