发明授权
US06972013B1 Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
有权
通过非侵入性体内电穿孔增强裸DNA的表达
- 专利标题： Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
- 专利标题（中）： 通过非侵入性体内电穿孔增强裸DNA的表达
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申请号： US10233007申请日： 2002-08-30
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公开(公告)号： US06972013B1公开(公告)日： 2005-12-06
- 发明人: Lei Zhang , Dietmar P. Rabussay
- 申请人： Lei Zhang , Dietmar P. Rabussay
- 申请人地址： US CA San Diego
- 专利权人： Genetronics, Inc.
- 当前专利权人： Genetronics, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Bio Technology Law Group
- 代理商 Daniel M. Chambers; Douglas C. Murdock
- 主分类号： A61N1/30
- IPC分类号： A61N1/30 ; A61N1/32
摘要：
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
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