发明授权
US06974815B2 Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
有权
可用作抗炎剂的六氢 - 苯并咪唑酮化合物
- 专利标题： Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
- 专利标题（中）： 可用作抗炎剂的六氢 - 苯并咪唑酮化合物
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申请号： US10681924申请日： 2003-10-09
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公开(公告)号： US06974815B2公开(公告)日： 2005-12-13
- 发明人: T G. Murali Dhar , Dominique Potin , Magali Jeannine Blandine Maillet , Michele Launay , Eric Antoine Nicolai , Edwin J. Iwanowicz
- 申请人： T G. Murali Dhar , Dominique Potin , Magali Jeannine Blandine Maillet , Michele Launay , Eric Antoine Nicolai , Edwin J. Iwanowicz
- 申请人地址： US NJ Princeton FR Rueil-Malmaison
- 专利权人： Bristol-Myers Squibb Company,Cerep SA
- 当前专利权人： Bristol-Myers Squibb Company,Cerep SA
- 当前专利权人地址： US NJ Princeton FR Rueil-Malmaison
- 代理商 Laurelee A. Duncan
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K31/415 ; A61K31/4184 ; A61K31/4188 ; A61K31/437 ; A61K31/4745 ; C07D235/26 ; C07D237/26 ; C07D403/10 ; C07D471/02
摘要：
The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K is O or S; Q is —C(═O)— or optionally substituted C1-4alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3, and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Z is N or C(R9); and R1, R2, R3 and R9 are as defined in the specification.