- 专利标题： Substituted alcohols useful in treatment of Alzheimer's disease
-
申请号： US10183126申请日： 2002-06-27
-
公开(公告)号： US06982264B2公开(公告)日： 2006-01-03
- 发明人: Varghese John , Roy Hom , John Tucker
- 申请人： Varghese John , Roy Hom , John Tucker
- 申请人地址： US CA South San Francisco
- 专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D403/12 ; A61K31/4178 ; A61P25/28
摘要：
The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
公开/授权文献
信息查询
