Invention Grant
- Patent Title: Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
- Patent Title (中): 含铜胺氧化酶的碳环肼抑制剂
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Application No.: US09902789Application Date: 2001-07-12
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Publication No.: US06982286B2Publication Date: 2006-01-03
- Inventor: David John Smith , Ferenc Fülöp , Marjo Pihlavisto , László Lázár , Sakari Alaranta , Petri Vainio , Zsolt Szakonyi
- Applicant: David John Smith , Ferenc Fülöp , Marjo Pihlavisto , László Lázár , Sakari Alaranta , Petri Vainio , Zsolt Szakonyi
- Applicant Address: FI Turku
- Assignee: Biotie Therapies Corp.
- Current Assignee: Biotie Therapies Corp.
- Current Assignee Address: FI Turku
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K31/135
- IPC: A61K31/135

Abstract:
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.
Public/Granted literature
- US20030125360A1 Carbocyclic hydrazino inhibitors of copper-containing amine oxidases Public/Granted day:2003-07-03
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