发明授权
- 专利标题： Polyanionic polymers which enhance fusogenicity
- 专利标题（中）： 增强融合性的聚阴离子聚合物
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申请号： US09674191申请日： 1999-04-27
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公开(公告)号： US06986902B1公开(公告)日： 2006-01-17
- 发明人: Tao Chen , Yuehua He , Peter Cullis , Thomas Madden , Peter Scherrer , David Tirrell , Phalgun Joshi , Jung Soo Kim
- 申请人： Tao Chen , Yuehua He , Peter Cullis , Thomas Madden , Peter Scherrer , David Tirrell , Phalgun Joshi , Jung Soo Kim
- 申请人地址： CA Burnaby
- 专利权人： Inex Pharmaceuticals Corporation
- 当前专利权人： Inex Pharmaceuticals Corporation
- 当前专利权人地址： CA Burnaby
- 代理机构： Oppedahl & Larson LLP
- 国际申请： PCT/US99/09076 WO 19990427
- 国际公布： WO99/55743 WO 19991104
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; C08G63/48 ; C08G67/02 ; C08F265/08
摘要：
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.
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