发明授权
US06991795B1 Protein delivery system using human papillomavirus virus-like particles
有权
使用人乳头瘤病毒病毒样颗粒的蛋白质递送系统
- 专利标题： Protein delivery system using human papillomavirus virus-like particles
- 专利标题（中）： 使用人乳头瘤病毒病毒样颗粒的蛋白质递送系统
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申请号： US09762794申请日： 1999-08-10
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公开(公告)号： US06991795B1公开(公告)日： 2006-01-31
- 发明人: Robert S. Lowe , Kathrin U. Jansen , Joseph G. Joyce , William L. McClements , James C. Cook, III , Jessica Ching-Yee Ling , Michael P. Neeper
- 申请人： Robert S. Lowe , Kathrin U. Jansen , Joseph G. Joyce , William L. McClements , James C. Cook, III , Jessica Ching-Yee Ling , Michael P. Neeper
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Alysia A. Finnegan; Joanne M. Giesser
- 国际申请： PCT/US99/17931 WO 19990810
- 国际公布： WO00/09157 WO 20000224
- 主分类号： C12N7/04
- IPC分类号： C12N7/04 ; C07K14/025 ; A61K39/12
摘要：
Human Papillomavirus virus like particles (VLPs) have been constructed so that they contain a modified L2 protein. The L2 protein has been minimized and is fused to a second protein or peptide. The fused protein is incorporated into the VLP and the VLP can deliver the protein to a cell. The modified VLPs can be used to increase the breadth of immune response in vaccine preparations or to deliver other proteins of interest.
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