发明授权
US06994974B1 Intracellular amyloid-beta binding (ERAB) polypeptide-related assays
失效
细胞内淀粉样蛋白-β结合（ERAB）多肽相关测定
- 专利标题： Intracellular amyloid-beta binding (ERAB) polypeptide-related assays
- 专利标题（中）： 细胞内淀粉样蛋白-β结合（ERAB）多肽相关测定
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申请号： US09394204申请日： 1999-09-10
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公开(公告)号： US06994974B1公开(公告)日： 2006-02-07
- 发明人: David M. Stern , Shi Du Yan
- 申请人： David M. Stern , Shi Du Yan
- 申请人地址： US NY New York
- 专利权人： The trustees of Columbia University in the city of New York
- 当前专利权人： The trustees of Columbia University in the city of New York
- 当前专利权人地址： US NY New York
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White, Esq.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention provides an isolated nucleic acid encoding an endoplasmic reticulum associated amyloid-beta peptide binding (ERAB) polypeptide. The ERAB polypeptide may comprise human ERAB polypeptide. The present invention provides a purified ERAB polypeptide, as well as a method for treating a neurodegenerative condition in a subject which comprises administering to the subject an agent in amount effective to inhibit ERAB polypeptide binding to amyloid-beta peptide so as to thereby treat the neurodegenerative condition.
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