Invention Grant
US06995183B2 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
有权
基于金刚烷基甘氨酸的二肽基肽酶IV抑制剂及方法
- Patent Title: Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
- Patent Title (中): 基于金刚烷基甘氨酸的二肽基肽酶IV抑制剂及方法
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Application No.: US10899641Application Date: 2004-07-27
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Publication No.: US06995183B2Publication Date: 2006-02-07
- Inventor: Lawrence G. Hamann , Ashish Khanna , Mark S. Kirby , David R. Magnin , Ligaya M. Simpkins , James C. Sutton , Jeffrey Robl
- Applicant: Lawrence G. Hamann , Ashish Khanna , Mark S. Kirby , David R. Magnin , Ligaya M. Simpkins , James C. Sutton , Jeffrey Robl
- Applicant Address: US NJ Princeton
- Assignee: Bristol Myers Squibb Company
- Current Assignee: Bristol Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Jonathan N. Provoost
- Main IPC: A61K31/403
- IPC: A61K31/403 ; A61K31/426 ; A61K31/4453 ; C07D209/52 ; C07D205/04 ; C07D295/00 ; C07D279/12 ; C07D259/03 ; C07D221/00 ; C07D295/16
Abstract:
Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20050038020A1 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods Public/Granted day:2005-02-17
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