发明授权
US06998494B2 Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
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反式熔融的3,3a，8,12b-四氢-2h-二苯并[3,4：6,7]环庚并[1,2-b]呋喃衍生物的制备
![Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives](/docs/US/2006-02-14/US06998494B2/abs.jpg.600x600.jpg)
- 专利标题： Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
- 专利标题（中）： 反式熔融的3,3a，8,12b-四氢-2h-二苯并[3,4：6,7]环庚并[1,2-b]呋喃衍生物的制备
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申请号： US10496279申请日： 2002-12-02
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公开(公告)号： US06998494B2公开(公告)日： 2006-02-14
- 发明人: Yolande Lydia Lang , Bart Petrus Anna Maria Jozef Medaer , Georges Joseph Cornelius Hoornaert , Thierry Brossette , Frans Josef Cornelius Compernolle , Michel Joseph Maurice André Guillaume , Hua Mao , Tomasz Kozlecki
- 申请人： Yolande Lydia Lang , Bart Petrus Anna Maria Jozef Medaer , Georges Joseph Cornelius Hoornaert , Thierry Brossette , Frans Josef Cornelius Compernolle , Michel Joseph Maurice André Guillaume , Hua Mao , Tomasz Kozlecki
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 优先权： EP01204961 20011207
- 国际申请： PCT/EP02/13560 WO 20021202
- 国际公布： WO03/048146 WO 20030612
- 主分类号： C07D307/93
- IPC分类号： C07D307/93
![Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives](/abs-image/US/2006/02/14/US06998494B2/abs.jpg.150x150.jpg)
摘要：
The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
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