发明授权
US06998495B2 Method for producing optically active 3,5-dihydroxycarboxylic acid derivative
失效
光学活性3,5-二羟基羧酸衍生物的制造方法
- 专利标题： Method for producing optically active 3,5-dihydroxycarboxylic acid derivative
- 专利标题（中）： 光学活性3,5-二羟基羧酸衍生物的制造方法
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申请号： US10492507申请日： 2002-10-24
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公开(公告)号： US06998495B2公开(公告)日： 2006-02-14
- 发明人: Masanobu Sugawara , Kenji Inoue
- 申请人： Masanobu Sugawara , Kenji Inoue
- 申请人地址： JP Kita-Ku
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： JP Kita-Ku
- 代理机构： Brinks Hofer Gilson & Lione
- 优先权： JP2001-327019 20011024
- 国际申请： PCT/JP02/11036 WO 20021024
- 国际公布： WO03/040082 WO 20030515
- 主分类号： C07C51/36
- IPC分类号： C07C51/36
摘要：
A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical.An optically active 3,5-dihydroxyhexanoic acid derivative is produced by asymmetrical hydrogenation of an optically active 3-oxo-5-hydroxyhexanoic acid derivative catalyzed by an RuBr2BINAP complex prepared from a ruthenium complex and a ruthenium-optically active phosphine complex, i.e., 2,2′-bisdiarylphosphino-1,1′-binaphthyl (BINAP), while using extremely inexpensive hydrogen as the reductant.