A disk drive anchoring mechanism adopted for use on a computer casing includes fastening elements, a bracing board, latch flanges and a drawing rack. The fastening elements are located on two opposite sides of a disk drive. The bracing board is fixedly mounted on the computer casing for holding the disk drive. The latch flanges are located on the bracing board corresponding to the two opposite sides of the disk drive and sandwich the disk drive therebetween through the fastening elements. The drawing rack is movably coupled with the latch flanges to confine the fastening elements to anchor the disk drive. Thus the disk drive may be installed or removed rapidly with hands without using screw drives to save time.