发明授权
- 专利标题： Substituted diarylamines as MEK inhibitors
- 专利标题（中）： 取代的二芳基胺作为MEK抑制剂
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申请号： US10221522申请日： 2001-03-12
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公开(公告)号： US07001905B2公开(公告)日： 2006-02-21
- 发明人: Cathlin Biwersi , Haile Tecle , Joseph Scott Warmus
- 申请人： Cathlin Biwersi , Haile Tecle , Joseph Scott Warmus
- 申请人地址： US NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： US NJ Morris Plains
- 代理商 Bryan C. Zielinski; Galina M. Yakovleva
- 国际申请： PCT/US01/07816 WO 20010312
- 国际公布： WO01/68619 WO 20010920
- 主分类号： C07D265/22
- IPC分类号： C07D265/22 ; C07C237/30 ; C07C237/32 ; A61K31/536 ; A61K31/166
摘要：
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.
公开/授权文献
- US20030225076A1 5-Amide substituted diarylamines as mex inhibitors 公开/授权日：2003-12-04
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