发明授权
- 专利标题： Modulators of Protein Tyrosine Phosphatases (PTPases)
- 专利标题（中）： 蛋白酪氨酸磷酸酶（PTPases）的调节剂
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申请号： US09662457申请日： 2000-09-11
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公开(公告)号： US07019026B1公开(公告)日： 2006-03-28
- 发明人: Henrik Sune Andersen , Thomas Kruse Hansen , Jesper Lau , Niels Peter Hundahl Møller , Ole Hvilsted Olsen , Frank Urban Axe , Yu Ge , Daniel Dale Holsworth , Todd Kevin Jones , Luke Milburn Judge , Wiliam Charles Ripka , Barry Zvi Shapira , Roy Teruyuki Uyeda
- 申请人： Henrik Sune Andersen , Thomas Kruse Hansen , Jesper Lau , Niels Peter Hundahl Møller , Ole Hvilsted Olsen , Frank Urban Axe , Yu Ge , Daniel Dale Holsworth , Todd Kevin Jones , Luke Milburn Judge , Wiliam Charles Ripka , Barry Zvi Shapira , Roy Teruyuki Uyeda
- 申请人地址： DK Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Bagsvaerd
- 代理商 Marc A. Began, Esq.; Richard W. Bork, Esq.; Rosemarie R. Wilk-Orescan, Esq.
- 优先权： DK199901278 19990910
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D409/04
摘要：
Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, wherein n, m, X, Y, R1, R2, R3, R4, R5 and R6 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
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