- 专利标题： Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
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申请号： US09904698申请日： 2001-07-13
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公开(公告)号： US07022496B2公开(公告)日： 2006-04-04
- 发明人: Gary Ketner , Julie L. Boyer
- 申请人： Gary Ketner , Julie L. Boyer
- 申请人地址： US MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore
- 代理机构： Whitman, Curtis & Christofferson, PC
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open reading frame 6 (ORF-6), (ii) neither the gene product of the E1A region nor the gene product of the E1B region is expressed, and (iii) no other early or late gene products are expressed. The present invention also provides methods of inhibiting repair of breaks in double-stranded DNA in a cell, preventing concatamerization of linear wild-type adenoviral DNA, inhibiting V(D)J recombination of nucleic acid sequences encoding immunoglobulins, preventing apoptosis, and preventing and treating cancer.
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