发明授权
- 专利标题: Enzymatic resolution of aryl and thio-substituted acids
- 专利标题(中): 芳基和硫取代的酸的酶解
-
申请号: US10625404申请日: 2003-07-23
-
公开(公告)号: US07026143B2公开(公告)日: 2006-04-11
- 发明人: Jingyang Zhu , Li You , Brenda J. White , Shannon X. Zha , Paul M. Skonezny
- 申请人: Jingyang Zhu , Li You , Brenda J. White , Shannon X. Zha , Paul M. Skonezny
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Burton Rodney
- 主分类号: C12P11/00
- IPC分类号: C12P11/00
摘要:
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or —S—R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).
公开/授权文献
- US20040072310A1 Enzymatic resolution of aryl and thio-substituted acids 公开/授权日:2004-04-15
信息查询