发明授权
- 专利标题: Process for preparing substituted phenylsulfonylureas from sulfonyl halides
- 专利标题(中): 从磺酰卤制备取代苯基磺酰脲的方法
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申请号: US10089288申请日: 2000-09-28
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公开(公告)号: US07026477B1公开(公告)日: 2006-04-11
- 发明人: Jan Vermehren , Ernst Schmidt , Mark James Ford , Richard W. G. Foster , Ian A. Bourne
- 申请人: Jan Vermehren , Ernst Schmidt , Mark James Ford , Richard W. G. Foster , Ian A. Bourne
- 申请人地址: DE Frankfurt
- 专利权人: Aventis CropScience GmbH
- 当前专利权人: Aventis CropScience GmbH
- 当前专利权人地址: DE Frankfurt
- 代理机构: Frommer Lawrence & Haug LLP
- 优先权: DE19946341 19990928
- 国际申请: PCT/EP00/09466 WO 20000928
- 国际公布: WO01/23368 WO 20010405
- 主分类号: C07D251/18
- IPC分类号: C07D251/18
摘要:
The invention relates to a preparation process for a compound (I) or a salt thereof, in which Q, X*, Y, Z, R, R1, R2 and R3 are as defined in claim 1, which comprises a) ammonolyzing a comp. (II) in which Hal=halogen atom to give (III), pref. (a1) carrying out the reaction in an organic solvent mixture (org. solv. mixture) comprising (1) opt. halogenated aromatic hydrocarbons and (2) polar aprotic solvents, in a weight ratio of solv. (1): solv. (2) of 20:1 to 1:1, (b) phosgenating the comp. (III) with phenylsulfonyl isocyanate of the formula (IV), pref. (b1) in the case X*=halogen, carrying out the reaction with phosgene in an org. solv. in the presence of isocyanates R′-NCO as catalyst, where R′=(subst.) hydrocarbon, with or without addition of an amine base, (c) reacting the resulting compound (IV) in org. solv. with the aminoheterocycle H2N-Het (Het=heterocycle as in (I)) to give the comp. (I) or a salt thereof, pref. (c1) carrying out the reaction in a solv. mixture of opt. halogenated arom. hydrocarbon having a b.p. of more than 110° C. and a polar aprotic solv., where at least one of the preferred partial steps (a1) to (c1) is carried out in the process.
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