发明授权
- 专利标题： Optically active amine derivatives and preparation process therefor
- 专利标题（中）： 光学活性胺衍生物及其制备方法
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申请号： US10416185申请日： 2001-11-09
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公开(公告)号： US07026515B2公开(公告)日： 2006-04-11
- 发明人: Hidetoshi Tsunoda , Kunio Okumura , Kengo Otsuka
- 申请人： Hidetoshi Tsunoda , Kunio Okumura , Kengo Otsuka
- 申请人地址： JP Tokyo
- 专利权人： Mitsui Chemicals, Inc.
- 当前专利权人： Mitsui Chemicals, Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Buchanan Ingersoll PC
- 国际申请： PCT/JP01/09830 WO 20011109
- 国际公布： WO02/38532 WO 20020516
- 主分类号： C07C215/30
- IPC分类号： C07C215/30 ; C07C215/46 ; C07C213/02 ; C07C213/08 ; C07C271/16
摘要：
A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula (3), which is then treated with an acid to provide an optically active aminoketone represented by formula (4). The product is then converted into an optically active aminoalcohol represented by formula (5) or (6) by, for example reduction.
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