发明授权
US07034152B2 Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
有权
制备抗病毒剂的方法[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤 -6-one
![Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/docs/US/2006-04-25/US07034152B2/abs.jpg.600x600.jpg)
- 专利标题： Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- 专利标题（中）： 制备抗病毒剂的方法[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤 -6-one
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申请号： US10734012申请日： 2003-12-11
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公开(公告)号： US07034152B2公开(公告)日： 2006-04-25
- 发明人: Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
- 申请人： Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Warren K. Volles
- 主分类号： C07D473/18
- IPC分类号： C07D473/18 ; C07D7/08 ; C07D473/40 ; C07F7/10 ; C07F7/18
![Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2006/04/25/US07034152B2/abs.jpg.150x150.jpg)
摘要：
Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.