- 专利标题: Inhibitors of glycogen synthase kinase 3
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申请号: US10309535申请日: 2002-12-03
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公开(公告)号: US07037918B2公开(公告)日: 2006-05-02
- 发明人: John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
- 申请人: John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
- 申请人地址: US CA Emeryville
- 专利权人: Chiron Corporation
- 当前专利权人: Chiron Corporation
- 当前专利权人地址: US CA Emeryville
- 代理商 Dennis K. Shelton; Young J. Suh; Alisa A. Harbin
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; A61K31/535 ; A61K31/47 ; A61K31/475 ; A61K31/52
摘要:
New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
公开/授权文献
- US20030130289A1 Inhibitors of glycogen synthase kinase 3 公开/授权日:2003-07-10