发明授权
US07045326B2 Mono- and diacylglycerol acyltransferases and methods of use thereof
失效
单和二酰基甘油酰基转移酶及其使用方法
- 专利标题： Mono- and diacylglycerol acyltransferases and methods of use thereof
- 专利标题（中）： 单和二酰基甘油酰基转移酶及其使用方法
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申请号： US10046924申请日： 2002-01-14
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公开(公告)号： US07045326B2公开(公告)日： 2006-05-16
- 发明人: Sylvaine Cases , Scot J. Stone , Ping Zhou , Robert V. Farese, Jr. , Chi-Liang Eric Yen
- 申请人： Sylvaine Cases , Scot J. Stone , Ping Zhou , Robert V. Farese, Jr. , Chi-Liang Eric Yen
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Bozicevic, Field & Francis, LLP
- 代理商 Paula A. Borden; Bret E. Field
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C07H21/04
摘要：
Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2α and MGAT1 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2α and MGAT1 activity; DGAT2α and MGAT1 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.