发明授权
US07045341B2 Chemoenzymatic process for stereoselective preparation of R and S enatiomers of 2-hydroxy-3-(2-thienyl) propanenitrile
有权
用于立体选择性制备2-羟基-3-（2-噻吩基）丙腈的R和S对映体的化学酶法
- 专利标题： Chemoenzymatic process for stereoselective preparation of R and S enatiomers of 2-hydroxy-3-(2-thienyl) propanenitrile
- 专利标题（中）： 用于立体选择性制备2-羟基-3-（2-噻吩基）丙腈的R和S对映体的化学酶法
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申请号： US10393406申请日： 2003-03-20
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公开(公告)号： US07045341B2公开(公告)日： 2006-05-16
- 发明人: Ahmed Kamal , Bhasker Ramesh Khanna Gollapalli , Ramu Rondla , Venkateswara Rao Maddamsetty
- 申请人： Ahmed Kamal , Bhasker Ramesh Khanna Gollapalli , Ramu Rondla , Venkateswara Rao Maddamsetty
- 申请人地址： IN New Delhi
- 专利权人： Council of Scientific and Industrial Research
- 当前专利权人： Council of Scientific and Industrial Research
- 当前专利权人地址： IN New Delhi
- 代理机构： Ladas & Parry LLP
- 主分类号： C12P41/00
- IPC分类号： C12P41/00
摘要：
A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates were prepared by enzymatic resolution of (±)3-hydroxy-3-(2-thienyl) propanenitrile both by transesterification and by hydrolysis reaction which were then transformed to both enantiomers of duloxetine.
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