Invention Grant
US07045629B2 Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane
有权
2- [-5-（4-氟苯基）-3-吡啶基甲基氨基甲基] - 苯并二氢吡喃的制备方法
![Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane](/docs/US/2006-05-16/US07045629B2/abs.jpg.600x600.jpg)
- Patent Title: Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane
- Patent Title (中): 2- [-5-（4-氟苯基）-3-吡啶基甲基氨基甲基] - 苯并二氢吡喃的制备方法
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Application No.: US10475988Application Date: 2002-04-08
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Publication No.: US07045629B2Publication Date: 2006-05-16
- Inventor: Heinz-Hermann Bokel , Steffen Neuenfeld , Ludwig Gantzert , Ralf Knierieme , Elke Simon , Ralf Devant , Udo Helm , Helmut Reubold
- Applicant: Heinz-Hermann Bokel , Steffen Neuenfeld , Ludwig Gantzert , Ralf Knierieme , Elke Simon , Ralf Devant , Udo Helm , Helmut Reubold
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: DE10120619 20010426
- International Application: PCT/EP02/03857 WO 20020408
- International Announcement: WO02/088117 WO 20021107
- Main IPC: C07D401/00
- IPC: C07D401/00
![Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane](/abs-image/US/2006/05/16/US07045629B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
Public/Granted literature
- US20040138266A1 Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane Public/Granted day:2004-07-15
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