- 专利标题： I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
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申请号： US10713208申请日： 2003-11-17
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公开(公告)号： US07056516B2公开(公告)日： 2006-06-06
- 发明人: Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
- 申请人： Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
- 申请人地址： US MD Rockville US MI Ann Arbor
- 专利权人： Human Genome Sciences, Inc.,The Regents of the University
- 当前专利权人： Human Genome Sciences, Inc.,The Regents of the University
- 当前专利权人地址： US MD Rockville US MI Ann Arbor
- 代理机构： Human Genome Sciences, Inc.
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C07K14/00 ; C12P21/08
摘要：
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
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