发明授权
US07070771B1 Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
失效
在人CD40 +细胞中表达嵌合小鼠和人CD40配体的方法
- 专利标题： Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
- 专利标题（中）： 在人CD40 +细胞中表达嵌合小鼠和人CD40配体的方法
-
申请号： US08982272申请日： 1997-12-01
-
公开(公告)号： US07070771B1公开(公告)日： 2006-07-04
- 发明人: Thomas J. Kipps , Sanjai Sharma , Mark Cantwell
- 申请人： Thomas J. Kipps , Sanjai Sharma , Mark Cantwell
- 申请人地址： US CA Oakland
- 专利权人： Regents of the University of California
- 当前专利权人： Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/87 ; C07H21/04
摘要：
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.
信息查询
