发明授权
- 专利标题： 14094, a novel human trypsin family member and uses thereof
- 专利标题（中）： 14094，一种新型人胰蛋白酶家族成员及其用途
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申请号： US09846512申请日： 2001-05-01
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公开(公告)号： US07071004B1公开(公告)日： 2006-07-04
- 发明人: Rachel Meyers , Kyle J. Macbeth
- 申请人： Rachel Meyers , Kyle J. Macbeth
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Millennium Pharmaceuticals, Inc.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.