- 专利标题： Method of modifying the release profile of sustained release compositions
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申请号： US10758717申请日： 2004-01-16
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公开(公告)号： US07074432B2公开(公告)日： 2006-07-11
- 发明人: James R. Dasch , M. Gary I. Riley
- 申请人： James R. Dasch , M. Gary I. Riley
- 申请人地址： US MA Cambridge
- 专利权人： Alkermes Controlled Therapeutics, Inc.
- 当前专利权人： Alkermes Controlled Therapeutics, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/52
摘要：
The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the biologically active agent incorporated therein, and a bisphosphonate wherein the bisphosphonate compound is present in an amount sufficient to modify the release profile of the biologically active agent from the sustained release composition. Pharmaceutical compositions suitable for use in the method of the invention are also disclosed.