Invention Grant
US07078014B2 Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
失效
使用二氢卟酚和细菌氯胺基氨基苯基DTPA和N2S2共轭物用于MR造影剂和放射性药物的方法
- Patent Title: Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
- Patent Title (中): 使用二氢卟酚和细菌氯胺基氨基苯基DTPA和N2S2共轭物用于MR造影剂和放射性药物的方法
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Application No.: US10390438Application Date: 2003-03-17
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Publication No.: US07078014B2Publication Date: 2006-07-18
- Inventor: Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
- Applicant: Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
- Applicant Address: US NY Buffalo
- Assignee: Health Research, Inc.
- Current Assignee: Health Research, Inc.
- Current Assignee Address: US NY Buffalo
- Agent Michael L. Dunn
- Main IPC: A61B5/055
- IPC: A61B5/055
Abstract:
A method for MR imaging that comprises conducting the MR imaging after injecting compositions that are chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99, Gadolinium, Indium111 and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The method uses the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc99, In111 or Gd(III) complexes of compounds of the formula:
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