发明授权
US07081241B1 Extracellular rage binding protein (EN-RAGE) and uses thereof
失效
细胞外rage结合蛋白（EN-RAGE）及其用途
- 专利标题： Extracellular rage binding protein (EN-RAGE) and uses thereof
- 专利标题（中）： 细胞外rage结合蛋白（EN-RAGE）及其用途
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申请号： US09167705申请日： 1998-10-06
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公开(公告)号： US07081241B1公开(公告)日： 2006-07-25
- 发明人: Ann Marie Schmidt , David Stern
- 申请人： Ann Marie Schmidt , David Stern
- 申请人地址： US NY New York
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White, Esq.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide, which comprises: (a) admixing: (i) a RAGE peptide or an sRAGE peptide or a fragment of either thereof, (ii) an EN-RAGE peptide or a fragment thereof, and (iii) the compound; (b) measuring the level of interaction between the peptide of step (a)(i) and the peptide of step (a)(ii), and (c) comparing the amount of interaction meausred in step (b) with the amount measured between the peptide of step (a) (i) and the peptide of step (a) (ii) in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the EN-RAGE peptide with the RAGE peptide, wherein a reduction in the amount of interaction in the presence of the compound indicates that the compound is capable of inhibiting the interaction. The present invention also provides for a method for inhibiting inflammation in a subject which comprises administering to the subject a compound capable of interfering with the interaction between EN-RAGE peptide and receptor for advanced glycation endproduct (RAGE) in the subject thereby inhibiting inflammation in the subject.
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