发明授权
- 专利标题： Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
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申请号： US10017718申请日： 2001-12-14
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公开(公告)号： US07081561B2公开(公告)日： 2006-07-25
- 发明人: Karl H. Weisgraber , Robert V. Farese , Robert Raffai , Li-Ming Dong
- 申请人： Karl H. Weisgraber , Robert V. Farese , Robert Raffai , Li-Ming Dong
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Bozicevic Field & Francis LLP
- 代理商 Paula A. Borden; Bret E. Field
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A01K67/00 ; G01N33/00 ; C12N15/00
摘要：
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.