发明授权
US07084123B2 Glucopyranosyloxypyrazole derivatives and use thereof in medicines
有权
吡喃葡萄糖氧吡唑衍生物及其在药物中的应用
- 专利标题: Glucopyranosyloxypyrazole derivatives and use thereof in medicines
- 专利标题(中): 吡喃葡萄糖氧吡唑衍生物及其在药物中的应用
-
申请号: US10451926申请日: 2001-12-25
-
公开(公告)号: US07084123B2公开(公告)日: 2006-08-01
- 发明人: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- 申请人: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2000-403534 20001228
- 国际申请: PCT/JP01/11348 WO 20011225
- 国际公布: WO02/053573 WO 20020711
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H17/00
摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug: one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
公开/授权文献
信息查询
IPC分类: