A multi-piece golf ball includes a core 30–40 mm in diameter, an intermediate layer including an outermost layer 0.5–2.0 mm thick, and a cover 0.5–2.0 mm thick. The core is a rubber composition mainly containing polybutadiene. The outermost layer is a resin material containing an ionomer resin in an amount of 30% by weight or more. The cover material is obtained by dispersedly blending a silicone powder in a main resin containing an ionomer resin in an amount of 50% by weight or more. The hardness of the outermost layer is harder than the hardness of the core's a center portion. The hardness of the cover is harder than the hardness of the outermost layer. A difference in hardness between the cover and the center portion of the core satisfies a relation of 10≦(Durometer D hardness of cover−Durometer D hardness of center portion of core≦40.