- 专利标题: Glucopyranosyloxypyrazole derivatives and medicinal use thereof
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申请号: US10468454申请日: 2002-02-26
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公开(公告)号: US07087579B2公开(公告)日: 2006-08-08
- 发明人: Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
- 申请人: Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2001-051278 20010226; JP2001-052903 20010227
- 国际申请: PCT/JP02/01707 WO 20020226
- 国际公布: WO02/068439 WO 20020906
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H17/00
摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.
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