A wireless pointing device with forced power-off function includes a body and a power supply switch. The body includes a pointing module, a battery, and a wireless transmission module. The wireless transmission module transmits an indication signal providing from the pointing module. The power supply switch is located on an outer surface of the body to control ON and OFF of the power supply circuit of the battery. The power supply switch may be cut off manually, or through charging operation to completely cut off the power of the wireless pointing device to avoid electric power consumption and increase the service life of the battery.